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[新闻] Projects 11711 & 11712 (GPU, Lin/Win, Core21) release to FAH

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发表于 2016-11-15 19:33:23 | 显示全部楼层 |阅读模式
本帖最后由 金鹏 于 2016-12-7 09:59 编辑

PPD普通的包
主要研究 膀胱癌,非小细胞和小细胞肺癌,慢性骨髓性白血病,肝细胞癌和胰腺癌,所以这个包必需算
Projects 11711 & 11712 (GPU, Lin/Win, Core21) release to FAH
by rafwiewiora » Mon Dec 05, 2016 11:50 pm
[size=1.3em]Projects 11711 and 11712 have joined FAH!

Stats:

11711:
# atoms: 31193 (mean over 11 RUNs, there is a slight variation)
credit: 14448
k-factor: 0.75
timeout: 7d
deadline: 10d

11712:
# atoms: 35094 (mean over 11 RUNs, there is a slight variation)
credit: 16571
k-factor: 0.75
timeout: 7d
deadline: 10d

Mixed precision is used (GPUs without DP are excluded).

In these projects, and already active on FAH 11707, 11708, 11709, and 11710 we are looking at histone lysine methyltransferase SETD8. This protein has been found overexpressed in a number of cancers including bladder cancer, non-small cell and small cell lung carcinoma, chronic myelogenous leukemia, hepatocellular carcinoma, and pancreatic cancer. In some cancers, it has been found to promote tumorigenesis, and it has been implicated in cancer invasiveness and metastasis [DOI: 10.1186/s13148-016-0268-4]. We are interested in understanding the conformational landscape of SETD8 in as much detail as possible, so that eventually selective small molecule inhibitors and chemical probes can be designed and tested. In these particular projects we’re looking at the histone methyltransferase SETD8 - in 3 different initial conformations - in all possible combinations with its co-factor SAM, by-product SAH, peptide substrate and methylated peptide product - we aim to explore conformations around all possible states of the catalytic cycle of this protein.

Projects 11711 and 11712 (GPU, LIN/WIN, Core21)
by rafwiewiora » Mon Nov 14, 2016 8:10 am
[size=1.3em]Projects 11711 and 11712 have joined BETA!

Stats:

11711:
# atoms: 31193 (mean over 11 RUNs, there is a slight variation)
credit: 14448
k-factor: 0.75
timeout: 7d
deadline: 10d

11712:
# atoms: 35094 (mean over 11 RUNs, there is a slight variation)
credit: 16571
k-factor: 0.75
timeout: 7d
deadline: 10d

Mixed precision is used (GPUs without DP are excluded).

In these projects, and already active on FAH 11707, 11708, 11709, and 11710 we are looking at histone lysine methyltransferase SETD8. This protein has been found overexpressed in a number of cancers including bladder cancer, non-small cell and small cell lung carcinoma, chronic myelogenous leukemia, hepatocellular carcinoma, and pancreatic cancer. In some cancers, it has been found to promote tumorigenesis, and it has been implicated in cancer invasiveness and metastasis [DOI: 10.1186/s13148-016-0268-4]. We are interested in understanding the conformational landscape of SETD8 in as much detail as possible, so that eventually selective small molecule inhibitors and chemical probes can be designed and tested. In these particular projects we’re looking at the histone methyltransferase SETD8 - in 3 different initial conformations - in all possible combinations with its co-factor SAM, by-product SAH, peptide substrate and methylated peptide product - we aim to explore conformations around all possible states of the catalytic cycle of this protein.

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发表于 2016-11-15 19:37:09 | 显示全部楼层
借楼问一下金版,帕斯卡最近加什么参数比较合适?现在手上的卡一直都是没有参数在跑。
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 楼主| 发表于 2016-11-15 19:40:30 | 显示全部楼层
horst1981 发表于 2016-11-15 19:37
借楼问一下金版,帕斯卡最近加什么参数比较合适?现在手上的卡一直都是没有参数在跑。 ...

按照每日日平均产出计算还是beta参数产出高

PS:GM/GP卡都加beta参数,只有780TI不加参数跑920X包破35万比较甜
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发表于 2016-11-15 20:04:52 来自手机 | 显示全部楼层
金鹏 发表于 2016-11-15 19:40
按照每日日平均产出计算还是beta参数产出高

PS:GM/GP卡都加beta参数,只有780TI不加参数跑920X包破35万比 ...

感谢指导^_^。回家就远程加参数。
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 楼主| 发表于 2016-11-15 20:19:43 | 显示全部楼层
horst1981 发表于 2016-11-15 20:04
感谢指导^_^。回家就远程加参数。

兄弟也比较一下同频同包时369.05和372.90哪个PPD高?
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发表于 2016-11-15 23:25:34 | 显示全部楼层
金鹏 发表于 2016-11-15 20:19
兄弟也比较一下同频同包时369.05和372.90哪个PPD高?

我去试试看
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发表于 2016-11-16 09:09:23 | 显示全部楼层
感觉这系列的包970(Linux下单卡1471MHz)跑得比较欢:

QQ截图20161116085641.jpg

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 楼主| 发表于 2016-11-16 09:23:56 | 显示全部楼层
Lynt 发表于 2016-11-16 09:09
感觉这系列的包970(Linux下单卡1471MHz)跑得比较欢:

兄弟的LINUX下PPD很高,WIN下就低了不少
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