April 29, 2006
Phase I Hall of Fame

The first version of the Phase I Hall of Fame is now available for your perusal. I will make updates as necessary should errors, etc., be uncovered, but this is pretty much going to be a static resource. Note that while the popups for node, member, and team information remain in place, the information in the popup windows reflects current, Phase II statistics, not those from Phase I.

You can access the Hall of Fame through the statistics front page or directly, at http://app.d2ol.com/stats/hof/hof.htm

Congratulations to everyone for a successful Phase I, and thank you very much for your enthusiastic participation. Lets make Phase II even better!

2006 年4月 29 日
Phase I光荣榜

Phase I光荣榜第一版发布。如果有必要，我将会更新，因为这是静态改起来比较麻烦。注意，当前node、用户和团队的Phase I数据都在，客户端弹出窗口的统计数据是Phase II, 不是Phase I的。

你能通过统计页面首页转到光荣榜，或者直接进入
http://app.d2ol.com/stats/hof/hof.htm

感谢大家为Phase I的成功所做的贡献，非常感谢你的热情。让我们把Phase II做的更好!

[ Last edited by vmzy on 2006-5-18 at 11:40 ]

May 02, 2006
May Project Status

Now that things have stabilized a bit after the start of Phase II and the Member Services crash in April, it's a good time to review recent events and the project status, as well as to lay out our plans for the coming weeks and months.


April 2006 Recap
================

1) Phase I of the project was completed on April 3 as we turned the page to Phase II. This new period was marked by:

a) A new Avian Flu target.
b) Two new candidate drug libraries.
c) Statistics server updates to prevent duplicate submission of results.

2) We experienced a hardware crash on April 5 that affected all aspects of Member Services and Statistics. Task downloads and uploads were unaffected, so the important work of finding drug candidates continued.
A temporary software workaround allowed the statistics server to continue.

The Memeber Services system was recovered during the last three weeks of the month through the following steps:

a) New hardware was purchased and brought online.
b) The Member Services database was restored from the quarterly backup of January 24, 2006.
c) Nodes that were created after January 24 and before the crash were manually re-created in the Member Services database.

Further, new data backup protocols have been established to hopefully make recovery a bit easier and more reproducible in the future should the unthinkable happen again.

3) A "Hall of Fame" was created as a historical record of all the hard work that went into Phase I. The statistics for nodes, members, and teams have been preserved for posterity, and you all have our hearty congratulations and deep gratitude for your devotion to this project.


Now, moving forward ...

Planned Activities
==================
1) After more than a week at 1000, the maximum queue size has been bumped up to 2000, where it will remain unless problems crop up. You should be getting your full complement of tasks.

2) Starting on or about this coming weekend (May 6-7), the "old" targets will be re-introduced to the system, only this time we'll be running them against the new drug candidates. Expect to see about one new/old target a week until we're back up to full speed.

3) More statistics server changes are planned. In particular, a "turnaround" time limit will be instituted to encourage more timely uploading of results and to discourage the accumulation of large amounts of results that need to be uploaded. The initial time limit will be one month, and we'll adjust from there as we gain more experience. This means that the results for each task need to be uploaded within a month of the assignment date or statistics won't be credited to the node that did the work. If something comes in late, the docking results will be collected, but the stats won't be incremented.

Obviously, since I'm just mentioning this now, I'm not going to turn this feature on tomorrow. My plan is to install this change around the middle of June.


As always, your questions and comments are welcomed.

2006 年5月 02 日
五月项目状态

四月在Phase II开始和Member Services崩溃之后，一切已经稳定一点了，现在是回顾最近的事件和项目状态，发布我们接下来的计划的好时机。


2006 年4月回顾
================

1) 项目的Phase I在4月 3 日完成，现在已进入Phase II阶段，这个新的阶段包含：

a) 一个新的禽流感目标。
b) 二个新的候选药物库。
c) 统计服务器更新，防止结果的重复上传。

2) 我们在4月 5 日遇到硬件损坏，影响了Member Services和统计的所有方面。任务下载和上传未受影响，因此，寻找候选药物的重要工作仍然在继续。
一个临时的软件让统计服务器继续工作。

Memeber Services系统在4月的最后三个星期，通过下列步骤被恢复:

a) 购买并使用新的硬件。
b) Member Services数据库被恢复至 2006 年1月 24 日。
c) 在1月 24 日崩溃之后加入的Nodes被手工重新加入Member Services数据库。

此外，创建了新的数据备份协议，希望将来能使恢复更容易些而且可再生，这种事情很可能会再次发生。

3) 创建一个Phase I的"光荣榜"记录所有辛苦工作的历史记录，node、用户和团队的统计已经保存以供后人查看，而且我们由衷的祝贺和深深的感谢你们为这个项目的热爱和付出。


现在，继续下一项……

计划活动
==================

1) 最大的缓存大小在被设为1000长达一个星期之后，已经升至 2000，如果不出问题，它将会保持。这下你应该可以得到足够的任务了。

2) 大概从这个周末开始(5月 6-7 日)，"旧"目标将会被再次系统，这次，我们只会在新的候选药物上运行他们。在我们全速开工后，可能每星期都加入一个新或旧的目标。

3) 对统计服务器进行较多的更新。特别是，将会加入"turnaround"期限，鼓励结果的及时的上传而且防止大量的需要上传的结果被积聚。开始的期限将会是一个月，而且稍后我们肯定会作出调整。这意谓着，每个任务的结果需要在一个月内上传，否则任务结果将不会被加入统计，也不会给予积分。如果，结果晚上传了，将会被收集，但是统计数据不会增加。

显然，如上所述，我不会明天就开启这个功能。我的计划是将在六月的中旬左右开始加入限制。

一如往常，欢迎你提疑问和意见。

译者注：我靠，连D2OL都要加“时间限制”了，无语了。这下生物类项目就只有FAH有没有“时间限制”的任务了，看来所有得慢机器只能来FAH了。

[ Last edited by vmzy on 2006-5-18 at 13:49 ]

July 08, 2006
July Project Status

It's been a couple of months since I've checked in with a project status update, so I thought you might all be interested in a recap of recent events and a preview of what's coming up.

May - June 2006
===============
Phase II continued to roll along, with more than 3 million candidate results returned to date. From the beginning of Phase II through the end of June, more than 1245 nodes came online to join the cause, and we now have over 80,000 registered nodes. Thank you all for your overwhelming interest and support!

During May and June, further updates were made to the statistics server to ensure more reliable and accurate tracking of your work. As a result of some of this development, task time limits were installed on July 5, with tasks currently expiring 31 days after they have been assigned. In addition, software was written to provide up-to-date candidate coverage information on the Statistics Snapshot page. This data can be used to help us decide when to retire a certain target/candidate library combination.


Upcoming
========
Unfortunately, due to some of the problems encountered with the statistics servers and the nature of the fixes and enhancements, I didn't get around to deploying the "old" targets with the new candidate libraries at the rate I wanted to. So getting these deployed is the next order of business, and you'll probably see at least one of these targets re-appear within the next week or so, paired with brand new candidates.

Also, you may recall from earlier announcements that we plan to publish an article about this project and the fine work you have all been doing for the last several years. I will be working on this project during the next month (or three!), and I'll keep you updated on our progress here. Being able to share our work with others is important, and these types of communications will help us in that regard.

Finally, I plan to begin looking into how we're going to eventually update our client, which I know is high on many of your wish lists. Changing the client presents fairly significant challenges, but I'm confident we'll get things ironed out and develop a flexible protocol that will allow us to respond to client-side issues. Here, too, I'll do my best to keep you in the loop.

As always, your questions and comments are welcomed.

2006年7月8日
7月项目信息
距离我上次更新项目信息，已经过去几个月了，我想你们可能很想知道最近发生了什么事件和近期的计划。

2006年5－6月
===============
阶段2继续进行，收到了超过三百万个结果。自六月底阶段2的开始，有超过1245个新节点加入，而且我们现在有超过80,000个注册的节点。谢谢大家的支持和厚爱!

在五月和六月间，对统计服务器进行了进一步的更新，以确保更可靠和更正确的记录你上传的任务结果。一些更新的成果，在7月5日为任务加入了计算时限，现在任务在被分配31天之后期满作废。除此之外，软件加入了在统计快照页面提供最新候选药物的资讯的功能。这些数据能用来帮助我们决定何时该放弃一个特定的目标/候选药物分子。

接下来
========
坏消息，由于遇到统计服务器和其它的一些维护问题，我没有按预期的速度为新的候选药物分子库部署"旧的"目标。因此只有推迟一下了，你或许会在几周后至少见到一个以上的配以全新的候选药物分子库的这类目标。

同时，你可能从较早的公告中已经知道，我们计划出版关于项目成果和在过去几年的大家所做的一切的文章。 在下个月 (或下三个月!)我将会完成它，而且我将把进度更新告知大家。能够与你们分享我们的工作很重要，而且好的沟通将会帮助我们完善自身。

最后，我计划开始研究如何更新我们的客户端，我知道你们大部份人都希望如此。更新客户端是一个非常重要的挑战，但是我坚信我们会顺利完成它，同时我们将会开发一个可以响应客户端事件的一个弹性较大的协议。在这里，我也将尽全力把可公开的信息告诉你。

一如往常，欢迎你的意见和建议。

[ Last edited by vmzy on 2006-7-18 at 16:50 ]

October 08, 2006
October Project Status

Our last project status update was in July, so it's high time for another one. I expect development activity to pick up in the next few months, so I'll plan on publishing updates at least monthly, if not more frequently.

July-September 2006
===================
You guys have exceeded your own lofty standards of crunching in the last few months. Since the last project update on July 5, you have returned about 4.5 million candidate results, and you're now uploading between 40,000 and 50,000 candidates a day. This is outstanding and you are to be commended on your dedication to this project!

In early July, we had just "turned on" candidate time limits, and I hadn't had much time to evaluate the impact to the project by the time of the last status update. Over the last few months, I've monitored the results coming in to see how many "expired" tasks are being returned. In the first week or so of time limits, some nodes were returning lots of expired tasks, but that seems to have become less of a problem as people have gotten the hang of downloading manageable chunks of tasks to work on. Currently, less than 1% of all returned results are expired. And remember, even if a task is expired, it is still saved, but it does not toward a node's statistics.

Along these lines, I'd like to know how you all feel about the time limits now that we've had them for awhile. Is 31 days working OK? Are there problems that the time limits are causing you? I've had a smattering of feedback, but no landslide of protest or yippees. Let me know if we need to change something.

I still have some of the old targets queued up and ready to be deployed with new candidates, but the coverage statistics show that we've still got awhile to go before we have really complete coverage of the targets deployed right now. In general, I'd like to keep a couple of targets active until we've pretty well exhausted them, and then move on (or back) to other targets.

In regards to client updates, you may have noticed the new forum area to discuss which features we'll put into the client update slated for 2007. This is the first step toward making sure that we get the features that are most important to the biggest segment of our users.

Finally, preparation work for the project review article continues, but it's going a little slower than I hoped and expected. I'm still committed to finishing the article, though, and I'll let you know how it's coming.

Upcoming
========
On the server side of the project, I have a few things line up for the not-too-distant future. One is a password utility that will allow you to reset your project password on your own. As I get ready to unroll these items, I may be asking for a few volunteers to try them out before they go live.

In the next couple of months, I'll continue to be asking for your input on features for the next release of the client, scheduled for 2007. The more input you provide, and the more discussion we can generate, the better the final product will suit your needs. Please plan to visit the requirements forum often!

I'll continue to monitor the coverage statistics and switch out targets when appropriate. Something we may want to consider is that the switchouts represent natural breakpoints in the project. We could take statistics snapshots at these times and save them as we did with the Hall of Fame, but without the overall statistics reset. At some point we could possibly have two sets of running stats: all-time and current. This way, we could have "seasons" in which to do our crunching. Let me know your thoughts

As always, your questions and comments are welcomed.

2006年10月8日
十月项目消息

我们上次是在七月更新项目消息的，因此，现在是发布新消息的时候了。我想在接下来的几个月里加快开发活动，因此，我至少每月发布更新消息。

2006年7-9月
===================
在最近的几月里你们做的太棒了。自从上次项目在7月5日更新以来，你们已经上传了大约450万个结果，而且你们现在每天要上传4-5万个结果。这太棒了，你们对这个项目所做的贡献值得表扬！

在七月初，我们正式 "开启" 了任务的时间限制，不过在上次消息更新前我没有太多的时间考虑它对项目造成的影响。在最近的几月，我检查了有多少 "过期 " 的结果被上传。在第一个星期里，一些节点上传了许多过期的任务，但是，这似乎并不是公共问题，因为这些人的网络出了问题，无法及时上传/下载。现在，不到 1% 的所有上传的结果是过期的。而且记住，即使一个任务过期，它仍然被保存，只是不加入该节点的数量统计而已。

我们已经照这样进行了一段时间了，我想要知道你现在对时间限制的看法。31天限制好吗？你是否遇到了问题？我已经有了些许的反馈、但是没有特别好或坏的意见。如果你觉得我们需要作出改变，就告诉我。

我仍然有一些需要针对新的候选分子库进行计算的旧目标在排队等待部署，但是统计显示我们还需要一段时间才能把现有目标完全算完。大体上，我会保持一定数量的目标开启，直到我们把他们全部算完，然后转移至其他的目标。

关于客户端更新，你可能已经注意到新开的论坛讨论区，讨论2007年的客户端更新应该加入哪些功能。这是重要的第一步，以确保我们新加的功能对我们的大部分使用者而言很重要。

最后，项目概览文章还在继续准备中，但是它比预期的进度要稍慢一些。不过我答应了会完成文章，而且我将会及时告诉你相关的消息。

接下来
========
至于项目的服务器，在不远的将来我已经安排满了一些事情。一是，密码工具，可以让你按自己的意愿重新设定你的项目密码。在我准备好公开这功能之前，我可能会要求一些志愿者进行测试。

在接下来的两个月，我将继续要求你提供 2007版客户端的功能需求。你提供越多的需求，我们就能进行更多的讨论，最终的产品也将会更适合你的需要。请常来需求论坛看看!

我将继续关注统计数据，并在适当的时候放出新的目标。我们可能想要考虑的事情是，每次发布新目标都代表着项目的阶段性成就。我们在这些时候，会把统计数据作个快照并且保存他们，就如同我们的名人堂一样，只是不用重置全部的统计数据。在某些时候，我们可能有二套统计数据：全部时间的和当前的。这样，我们可以 "阶段性" 地进行计算。告诉我你对此的想法。

一如往常，欢迎你的疑问和意见。

November 05, 2006
November Project Status
Just a quick project status update as we head into the last couple months of the year. Nothing major here, but I wanted to make sure we're all up to date.

October 2006
============
The big activity for October, aside from your continued production in crunching the candidates, was the beginning of requirements gathering for the updated client, scheduled to be releases sometime in 2007. You've provided lots of great ideas, and I'll start work on estimating these tasks soon.

I also began the process of updating our server-side programs to run on the latest version of JBoss. Some of the internal Jboss servers have already been upgraded, and I'll be working on the others in the next month or so.

Upcoming
========
I'd like to keep the requirements-gathering forums active for another month or so, and then figure out which are the most important features, and which are most feasible for implementation next year. Make sure you get any "must-haves" submitted pretty soon.

Jboss server upgrades will continue, hopefully further stabilizing our environment.

As always, your questions and comments are welcomed.

2006年11月5日
十一月项目消息
只是今年最后几个月的项目消息小更新。没啥重要的事，我只是想要确保大家知道最新的消息。

2006年10月
===================
十月的大活动，除了你们的继续计算候选药物之外，就是预定在 2007 年某刻发布的新客户端升级的需求搜集活动的开始。你们已经提供许多很棒的主意，而且我将很快开始对这些建议的评估工作。

我也开始将我们项目的服务器端程序使用的 JBoss 更新至最新版。一些内部服务器的 Jboss 已经升级了，而且我将在接下来的几个月里处理其余的服务器。

接下来
========
我想把需求搜集论坛，再开放一个月左右，然后挑选出最重要的、和最容易在明年落实的功能。所以抓紧提交您的"重要需求"吧。

Jboss 服务器升级将会继续，希望我们的运行环境的稳定性能提高一个档次。

一如往常，欢迎你的疑问和意见。

December 03, 2006
December Project Status

Just a quick project status update as we head into the December holidays.

November 2006
============
We continued to discuss requirements for client updates in 2007, and soon we’ll have some concrete plans for moving forward.

As you may have noticed, our forums have also run into the dreaded spam cycle, and some of the flotsam posted was a bit unsavory. I apologize for this material appearing here, even briefly, but we have taken steps to alleviate the problem. In particular, new registrations now go into an approval queue, and a personal e-mail exchange with me is required before the registration is accepted. We may be able to change this process at some point, but we’re currently getting a lot of undesirable registrations in the queue. I’ll keep you updated.


Upcoming
========
In the next couple of weeks or so, I’m going to post some information on a preliminary release schedule, with projected features and fixtures. We can continue to discuss and debate, but it’ll give us a baseline from which to launch our efforts.

I also plan to get back to the Jboss server upgrades soon, in an attempt to further stabilize our environment.

2006年12月3日
12月项目现状

马上就要到12月大假了，更新一下项目现状。

2006年11月
============
我们继续讨论将于2007年更新的客户端的需求分析，不久我们就会实施一些具体的计划。

你可能已经注意到，我们论坛遭遇恶意灌水，有很多垃圾内容。我很抱歉在这里出现这种内容，简单的说，我们已经采取措施减少它的影响。尤其是，现在采用了新的注册排队机制，并且通过注册前必须通过个人电子邮件与我进行交流。我们也许能通过这样，改变当前的一些状况。但目前我们的注册队列里有越来越多的恶意注册者。有新的消息我会通知你的。

接下来
========
在未来的数周里，我要公布一些有关项目功能和修缮的初步时间表。具体细节我们可以继续讨论和辩论，但它给我们工作的开展加上一个底线。

我还打算回去给服务器的JBoss进行升级，以便进一步提高系统环境的稳定性。

译者注：强烈BS在这种公益性论坛恶意灌水的无聊人士。

January 07, 2007
January Project Status

Happy New Year everyone! Welcome to the first project status update of 2007.

December 2006
=============
As I mentioned in last month's update, The Rothberg Institute was invaded by spammers November and December, and the forums were hit especially hard. We initially locked down the forums to require interaction with the administrators for any new registration to be completed. I've since implemented software changes that require a human to register an account and denies access to the various bots, without administrator involvement.

With your input, December also saw us lay out our preliminary release schedule for D2OL client changes in 2007. For more information, see the discussion topic here.

You may have also noticed that some of the old targets are being assigned with new drug candidates. The previous tasks are still available, so you'll be seeing a mix of three targets in all.


Upcoming
========
The major project activity over the first half of 2007 will be getting new versions of the client implemented and released. It should be a fun process, and when we're done, we'll have the ability to make more frequent changes if the need arises. This has been the case with the server side software, and I'm sure the same will hold true with the client.

Upgrades to the remaining Jboss servers remain another priority for 2007.


As always, your questions and comments are welcomed.

2007年1月7日
一月项目现状

新年好! 欢迎2007年第一个项目现状更新.

2006年12月
=============
正如我在上个月的更新中所说的，rothberg研究所在十一月和十二月被垃圾邮件攻击，而论坛受影响最大。开始我们限制了论坛注册，需要与管理员交流才能完成注册。后来我修改了注册软件，以防止各种“机器人”注册，无需管理员介入。

有你的帮助，12月我们也看到2007年新d2ol客户端修改的初步发布时间表。详见论坛帖子。

你可能也注意到，一些老对象正在针对新候选药物进行计算。以前的任务仍可用，所以你会看到总共三种计算对象。

接着
========
2007年上半年的主要项目活动将会是新版本客户端的实现和发布。它应该是一个有趣的过程，若有需要，我们可以边做边改进。服务器端和客户端软件都将不断改进。

2007年的另一件大事是升级其余的JBoss服务器。

一如既往，欢迎大家提问和评论。

2006年1月18日

We had some disk-space issues, which is why the stats for today haven't shown up. They'll go in this weekend.
我们遇到了一些硬盘空间的问题，所以今天的统计没有出现。它们将会在这个周末恢复。

译者注：我还以为我上传的20几个包通通被拒绝，伤心不已。不过现在似乎已经好了呢。

February 11, 2007
February Project Status

The Groundhog has come and gone, so it's time for our February project status update.

January 2007
=============
During January, I began working on the task of building new releases for the client for 2007. There has been a lot of overhead involved in this, including source code control issues, establishing a build process, and Java versioning issues. Most of these have been resolved, and I'm now working on installation tools for distributing our first beta version of the client for this year. If all goes well, we'll be testing some time in March.

Upcoming
========
Client update activities will continue to dominate my time over the next few months, first in creating a stable release environment and later in adding the features we have talked about in the past. Thanks for your input so far, and rest assured that I'll be relying more heavily on the community as we move into beta testing and beyond.

Another immediate activity for the project is the upgrading of our Java versions to handle expanded Daylight Savings Time here in the U.S. That update will happen over the next month or so.

2007年2月11日
2月项目总结

圣烛节（2月2日）已经过去了，是我们更新二月项目总结的时间了。

2007年1月
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在一月。我就开始了将于2007年发布的新版客户端的编程任务。有不少人参与这个工作，包括源代码控制问题，建立编程计划和Java版本问题。其中大部分已得到解决，而我现在正编写今年首发的供用户β测试的安装包。若一切顺利，会在三月进行测试。

接下来
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后几个月里我会把主要精力放在最新客户端的工作上。第一，创造一个稳定的内核，稍后加入我们之前讲过的新功能。谢谢您到目前为止的贡献，放心，进入β测试以后我会注意论坛里的反馈的。

项目的另一个工作是更新的Java语言版本以解决07年美国新颁布的Daylight Savings Time法令问题，会在下个月进行更新。

Greetings all,

I am still working out some kinks in the overall installation process we're going to use for the client releases this year, but I'd like to go ahead and start beta testing the 2007.1 client. As you'll recall, this version is basically just a rebuild of what you have now, with no functionality changes. We will be testing to verify that the build process is working OK. As such, need just a handful of testers at this point.

Because the installation scheme is not completely hammered out, you'll need to a do a couple of file copies to get the beta client running, but it should take you less than 10 minutes. If you're interested in helping out with this effort, send me a PM, and I'll get you going.

Thanks,
Adam

大意是：2007.1这个测试版本已经完成了，但是安装程序仍然没有完成，如果你有兴趣使用的话，可以在论坛里PM给Adam Hughes，不过必须要拷贝一些档案来使用这个测试版，但是这个过程会小于10分钟。

这个版本只是你现在所有的的一个重新编译的版本罢了～这次的测试是要测试这个版本是不是无错的，需要有经验的测试者来进行测试。