Project 11730 (GPU, Core21) in BETA!
高温高负载小甜包Project 11730 (GPU, Core21)https://foldingforum.org/styles/prosilver/imageset/icon_post_target_unread.gifby rafwiewiora » Sun Oct 21, 2018 11:42 amProject 11730 now in BETA!
Stats:
11730:
# atoms: 68613
credit: 8464
k-factor: 0.75
timeout: 7d
deadline: 10d
precision: mixed
We are running follow-up simulations for this awesome paper: https://www.biorxiv.org/content/early/2018/05/25/331637
"Protein kinases are crucial to coordinate cellular decisions and therefore their activities are
strictly regulated. We used ancestral resurrection to uncover a mechanism underlying the
evolution of kinase control within the ERK family of Mitogen Activated Protein Kinases (MAPKs).
Kinase activities switched from high to low intrinsic autophosphorylation at the transition from
the ancestors of ERKs1-5 and ERKs1-2. A shortening of the loop between b3-aC and a mutation in
the gatekeeper residue drove this transition. Molecular dynamics simulations suggested that the
change in the b3-aC loop length affected kinase cis-autophosphorylation by altering the
positioning of catalytic residues and by allowing greater flexibility in the L16 kinase loop. This
latter effect likely synergizes with the known role of gatekeeper mutations in facilitating domain
closure and thus kinase activation, providing a rationale for the synergy between the two
evolutionary mutations. Our results shed light on the evolutionary mechanisms that led to tight
regulation of a central kinase in development and disease."
Thanks folks!
据说这个包base分提高过了，现在更加甜了？ yimu35 发表于 2018-11-4 16:00
据说这个包base分提高过了，现在更加甜了？
没有吧……？2080Ti从第一次接到11730到现在一直都是240W+，瞬间最大也只见过249.4W，没突破过250W。
thomasbbq 发表于 2018-11-5 20:03
没有吧……？2080Ti从第一次接到11730到现在一直都是240W+，瞬间最大也只见过249.4W，没突破过250W。
...
overclock隊的洋人 現在能到280-290萬？OS不同？
看來base是沒變過，8464.
yimu35 发表于 2018-11-6 07:28
overclock隊的洋人 現在能到280-290萬？OS不同？
看來base是沒變過，8464.
我擦，这得抄到2100的2080TI才能跑出这个PPD
本帖最后由 vmzy 于 2018-11-12 17:05 编辑
这个wu比较坑，每10%一个存盘点，偶的半血版mx150 tpf是12分多。也就是基本上要等2个多小时才存一次盘，非7*24跑，表示很受伤 vmzy 发表于 2018-11-12 17:02
这个wu比较坑，每10%一个存盘点，偶的半血版mx150 tpf是12分多。也就是基本上要等2个多小时才存一次盘，非7 ...
不加Advanced，Beta 可以避开这个wu吧？这个wu基本属于高温高能耗小甜包。
vmzy 发表于 2018-11-12 17:02
这个wu比较坑，每10%一个存盘点，偶的半血版mx150 tpf是12分多。也就是基本上要等2个多小时才存一次盘，非7 ...
高压舔包适合桌面卡跑，兄弟不是7*24的确吃亏
yimu35 发表于 2018-11-12 17:31
不加Advanced，Beta 可以避开这个wu吧？这个wu基本属于高温高能耗小甜包。
...
不能，11730已经转正了，加不加Beta都会出。
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