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貌似PPD还可以
Projects 11718/19 (GPU, Core21)
Unread postby rafwiewiora » Sun Aug 19, 2018 10:03 am
Projects 11718 and 11719 now in BETA!
Stats:
11718:
# atoms: 50119
credit: 15047
k-factor: 0.75
timeout: 7d
deadline: 10d
precision: mixed
11719:
# atoms: 44691
credit: 12368
k-factor: 0.75
timeout: 7d
deadline: 10d
precision: mixed
The PRC2 complex is a therapeutic target for a number of cancers, currently undergoing clinical trials. It minimally consists of three proteins: EZH2, EED, and SUZ12. Its activity is regulated by a positive feedback loop, where the EED component reads already existing epigenetic marks and activates the EZH2 component to deposit more of them. Projects 11717-19 are looking at the dynamics of the three individual components of the complex (11718 - EED, 11719 - SUZ12). We are studying the allosteric mechanisms that control the functions of this molecular machine, as well as the potential for disrupting these mechanisms for the design of the next generation of inhibitors. Thanks folks!
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