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[项目新闻] [BOINC] [生命科学类] iGEM@home

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发表于 2014-10-25 22:14:14 | 显示全部楼层 |阅读模式
本帖最后由 2_958_859_071 于 2014-10-25 22:29 编辑

项目网址:
http://igemathome.org/igemathome/index.php

该项目发起团队为“ iGEM Team Heidelberg 2014http://2014.igem.org/Team:Heidelberg

主要研究“蛋白质折叠预测”,但又与 FAH 和 Rosetta 有所区别。
详见:
http://igemathome.org/project


2014-10-19
http://igemathome.org/igemathome/forum_thread.php?id=105

该项目 Wiki 已完成,详见:
http://igemathome.org/

发表于 2014-10-25 22:52:21 | 显示全部楼层
本帖最后由 swh@home 于 2014-10-26 09:27 编辑

看了一下,网站貌似很强大,内容很多。
PS:不该在新闻区插楼的说,为了弥补我的失误,勉强翻译了下面一段,欢迎拍砖!

下面这段主要讲与Folding@home 和 Rosetta@home 的区别:

Our Project

The project of Heidelberg's iGEM Team 2014 is dedicated to the modification of existing proteins, for example by attaching new structures to their ends and thereby changing the properties of the workhorses. As previously mentioned proteins have certain a function due to their conformation. So normally we don't want to destroy their original function, but how can we know whether the function is the same after we have attached parts? We analyze the new protein's folding with the attached sequences because if we choose the correct sequence between protein and our added part, we can minimize their influence on each other. But we have to try many different sequences (several hundred) with many different proteins (several thousand) to find out about the behavior of the sequences we try to attach.

根据Google翻译的结果,其大意是:这个项目是在现有蛋白质的基础上,加上新的结构对其进行修饰,从而达到改进原蛋白质某方面性能的目的,而又不想对原有的功能进行破坏。这就需要找到正确的折叠方法连接序列来使原有蛋白质与新加入结构之间的影响达到最小,但这必须要对数百结构和数千蛋白质进行大量不同的尝试。





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