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[注意] 9406/9408转正,9101继续ADV,新BETA包9201/13002上线

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发表于 2014-4-23 07:47:15 | 显示全部楼层 |阅读模式
本帖最后由 金鹏 于 2014-4-24 16:49 编辑
P9406 to full FAH
by cxh » Wed Apr 23, 2014 3:15 am
Here are some of the project details:

clones        5
min-core-version        46
natoms        78000
runs        1040
stats-credit        10500
timeout        3.5
deadline        4.5

In the same vein as 9401, this is a simulation of a disordered p53 peptide while binding to another protein. In this case, however, the binding partner is S100B, which is a cell cycle regulator. We hope to study how mutations in p53 may disrupt binding and, in the process, onset cancer.

Happy folding!
P9408 to full FAH
by cxh » Wed Apr 23, 2014 3:16 am
Here are the project details:

min-core-version        46
natoms        52940
runs        6220
stats-credit        13000
timeout        10.9
deadline        14.1

This is actually a clone of project 9401. Project 9401 was retired after a work server failure.
P9101 moving to adv
by msultan » Sat Apr 19, 2014 7:43 am
Hello all,
Moving 9101 to Advanced after testing on beta. It should be pretty stable.
Project Info:
The fyn kinase is an enzyme present in multiple signaling pathways whose aberrant behavior leads to cancerous cell growth, and has also been implicated in the invasion of the dengue virus. This project continues the Pande Lab's effort to map out the conformational landscape of the src kinase family. Recent work from our lab on a similar kinase found a potentially druggable intermediate state(Shukla et al, Nature2014). The main aim of the present simulation is to get a better understanding of Fyn's dynamics in order to design better therapeutics.

More Science:
The link between fyn and dengue: http://www.ncbi.nlm.nih.gov/pubmed/23616652
Recent Src Results: http://www.nature.com/ncomms/2014/14030 ... s4397.html

Some Project Stats:
client-type        beta
timeout        8.0
deadline        10.0
k-factor        0.75
gens        2000
min-core-version        46
natoms        ~33000
stats-credit        4000

Cheers,
Muneeb
New GPU Project 9201
by jadeshi » Wed Apr 23, 2014 8:05 am
Project description here: http://fah-web.stanford.edu/cgi-bin/fah ... ned?p=9201 (fah-web seems to be down at the moment of this post, however)
Transcribed (roughly):
This project is a simulation of Pin1 WW domain, which is a 40-residue protein arranged in an anti-parallel, 3-stranded beta sheet in the native state. It has been studied extensively in literature as a model system for the folding of beta sheets in general. Because beta sheets are ubiquitous structures in the proteome, gaining a firm understanding of the folding dynamics of this small representative system could potentially provide insights into the folding dynamics of countless other proteins. Experiments have suggested that the rate-limiting step to folding involves formation of the loop between the first and second strands, though no higher resolution structural information of the folding mechanism is available. This simulation will aim to establish an atomistic picture of the transition state ensemble and dominant folding pathways.

The long term vision of this project is to use the information obtained through the simulation to design small molecules to catalyze folding (i.e. stabilize the transition state). This small molecule catalysis methodology has direct applications to combating common protein misfolding diseases such as Alzheimer's and Parkinson's disease, and represents an alternative to the typical approach of directly destabilizing misfolded structures.

Specs:
OS: Win/Linux
stats credit: 4000
k-factor: 0.75
timeout: 2.6
deadline: 3.4
n_atoms: 15000
min core version: 46

contact: jadeshi@stanford.edu

Thanks!

目前转正CORE17包: 13000 13001  9406 9408  

强烈建议GF110 114核心费米卡跑9201,有超常的PPD表现





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发表于 2014-4-23 08:57:52 来自手机 | 显示全部楼层
现在推荐加啥参数呢?还是不加?
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发表于 2014-4-23 09:02:45 | 显示全部楼层
PPD要大涨的节奏?
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发表于 2014-4-23 09:14:18 | 显示全部楼层
现在好像A卡跑这个项目有优势。
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发表于 2014-4-23 09:45:11 | 显示全部楼层
本帖最后由 MixPioneers 于 2014-4-23 09:46 编辑

金版的好多文章,我真心看不懂
英文>数字>汉字
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发表于 2014-4-23 10:03:32 | 显示全部楼层
我这多卡 下载困难啊
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发表于 2014-4-23 10:43:46 | 显示全部楼层
zflowers 发表于 2014-4-23 10:03
我这多卡 下载困难啊

我也是下载上传困难,暂时又不想用电信宽带。真心还是WCG好,屯粮。
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发表于 2014-4-23 12:54:27 来自手机 | 显示全部楼层
wcg 是什麼公司来自: Android客户端
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发表于 2014-4-23 13:10:02 来自手机 | 显示全部楼层
scottlio 发表于 2014-4-23 12:54
wcg 是什麼公司

IBM
worldcommunitygrid.org
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发表于 2014-4-23 14:19:21 | 显示全部楼层
謝謝manho
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发表于 2014-4-23 18:33:01 来自手机 | 显示全部楼层
ManHo 发表于 5 小时前

IBM
worldcommunitygrid.org

啥意思,跟wcg有什么关系啊?来自: Android客户端
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发表于 2014-4-23 21:20:31 来自手机 | 显示全部楼层
9201狠甜,比9406更甜
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发表于 2014-4-23 21:34:15 来自手机 | 显示全部楼层
guihuo 发表于 2014-4-23 21:20
9201狠甜,比9406更甜


9201   7950@1090MHz  7-11w浮动
           280X@1100MHZ  8w-11.5w浮动

9406 7950   155-166k
          280X   158k-169k

甜么?
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发表于 2014-4-23 21:58:07 来自手机 | 显示全部楼层
ManHo 发表于 2014-4-23 21:34
9201   7950@1090MHz  7-11w浮动
           280X@1100MHZ  8w-11.5w浮动


甜 for N卡
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发表于 2014-4-24 00:59:04 | 显示全部楼层

GTX660 9101包 50k+
9406包 20-25k

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