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Working
at The Rothberg Institute |
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The Rothberg Institute for Childhood Diseases is a non-profit research institution devoted to discovering, developing and delivering to patients novel chemical and biological therapies for the treatment of Tuberous Sclerosis and other childhood diseases. We are applying innovating drug discovery strategies and operate at the intersection of molecular biology, chemistry, and nanotechnology. We are located on the picturesque Connecticut shoreline in Guilford, CT.
While our location offers panoramic views of Long Island Sound and the town marina, our facility is state of the art. TRI employees enjoy a rare opportunity to network with leading scientists, institutions and physicians in discovering and developing cures for childhood diseases – all within 20 minutes of Yale University and New Haven.
Tuberous Sclerosis Complex (TSC) is
a genetic disorder that leads to seizures and benign tumors
in multiple organs, including the brain, kidneys, heart,
eyes, and lungs. Understanding TSC will ultimately serve
as a Rosetta stone to understanding cancer.
For more information about our location,
please visit the Guilford, Connecticut home page at
www.guilfordct.com
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Postdoc - Chemistry: Antibody Engineering - Job code 06-01
We seek an individual to generate and evolve single chain antibody libraries utilizing in vitro transcription translation (IVT) in microdroplets. The focus is on developing antibody therapeutics for life threatening conditions associated with Tuberous Sclerosis Complex. This is a unique opportunity to leverage new microfluidic technologies being developed with the help of three Nobel laureates. Experience with antibody engineering, IVT and molecular biology techniques is required. The candidate must hold a Ph.D. in biochemistry or biophysics.
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Postdoc - Cell and Animal Models - Job code 06-02
The focus is on developing animal models from TSC cell lines and to utilize the piggyBac transposon technology developed in the laboratories of Prof. Tian Xu at Yale University to screen for transforming mutations specific to Tuberous Sclerosis Complex (Cell, Vol. 122, 473-483). The work will be conducted in collaboration with Prof. Tian Xu at Yale Medical School and requires experience with mammalian cell culture, animal handling and advanced molecular biology techniques. Experience with generating and using transgenic or nude mouse animal models in drug development required. The candidate must hold a Ph.D.
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Postdoc - Combinatorial Chemistry - Job code 06-03
We seek an individual to design, synthesize and characterize combinatorial libraries in aqueous media to support high-throughput screening. The focus is on developing small molecule leads for life threatening conditions associated with Tuberous Sclerosis Complex. This is a unique opportunity to leverage new microfluidics being developed with the help of three Nobel laureates. Prior synthetic experience in the aqueous phase and the synthesis of large combinatorial libraries is required. The candidate must hold a Ph.D. in synthetic organic chemistry.
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Postdoc - High-Throughput Screening of Drug Combinations - Job code 06-04
We seek an individual to design, synthesize and characterize combinatorial libraries in aqueous media to support high-throughput screening. The focus is on developing small molecule leads for life threatening conditions associated with Tuberous Sclerosis Complex. This is a unique opportunity to leverage new microfluidics being developed with the help of three Nobel laureates. Prior synthetic experience in the aqueous phase and the synthesis of large combinatorial libraries is required. The candidate must hold a Ph.D. in synthetic organic chemistry.
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Custodian - Job code 05-10
Seeking a full time Custodian/Groundskeeper for a waterfront BioTech facility.
Sole cleaning responsibility for a 14,000 Sq Ft facility with a mix of lab and office space.
Duties to include buffing & waxing, mopping, dusting, vacuuming, trash removal, restroom cleaning,
windows, and grounds cleanup. Light maintenance work will also be expected.
Shift is M-F 1pm to 9pm with flexibility to accommodate housekeeping for weekend conferences and seasonal chores.
We need a self motivated individual who can maintain the facility to such a manner that it is always
"tour ready". Must be willing to take on other responsibilities as assigned.
Requirements
• Minimum 2 years of custodial experience - a Bio Lab environment strongly preferred.
• Experience maintaining Vinyl Tile with waxing and buffing.
• Ability to carry a floor buffer up stairs - no elevator available.
• Able to lift at least 50lbs
• May be required to perform diverse physical tasks
Compensation is $13 per hour with benefit package.
Please email resume and cover letter, indicating job code to jobs@childhooddiseases.org
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We are looking for part time unpaid volunteers
in the areas listed below. We are also looking for general administrative
and bookkeeping assistants. For part time volunteers, particularly
in the sciences, you must work a minimum of 10 hours per week
in blocks of 3 hours.
We are also looking for summer interns to work
in our laboratories or on computer projects with a minimum time
commitment of 20 hours per week.
In addition, we are looking volunteers for:
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Administrative/Clerical - Job Code 03-V
Volunteers who have an area of expertise in accounting, purchasing,
and Human Resources are needed to support the day to day operations
of TRI. In addition, general clerical support is greatly appreciated.
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Internet Evangelist for CommunityTSC
We have an amazing software package to make drugs against TSC
(a Rosetta stone for Cancer) from your home computer without
any knowledge or experience, just your spare computer time.
Ten's of thousands of volunteers can support this effort in
running this program on their home computer. You can support
this project further by Web linking to major charity sites,
posting to major discussion boards, and by encouraging students
from universities and people from other charity organizations
to get involved. This is NOT looking for E.T. (Seti@home). This
is volunteering spare computer time to make drugs to cure children
that could die. And this is the real deal. This is the only
project of its kind with the resources and knowledge to get
the job done. No Job Code is needed.
Please email
resume and two letters of recommendation to jobs@childhooddiseases.org
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Interns
at The Rothberg Institute
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Biology Internship - Job Code 02-10
This position offers an excellent opportunity
for an enterprising young scientist with an interest in Biochemistry,
Biotechnology, Molecular or Cell Biology. You will assist
the Research Scientists and Associates in drug discovery research
at The Rothberg Institute. You will also have the opportunity
to contribute to a variety of cell biology experiments.
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Informatics Internship Job Code 03-06
Internship for undergraduate student with a background in
both Unix and Windows operating systems as well as networking
and firewall fundamentals to assist with infrastructure maintenance.
Experience communicating in a Forum Environment (i.e. UBB)
required. Communication skills must be powerful and clear,
appropriate for software support within an international community.
Must be very detail oriented with a habit for documentation.
Dreamweaver and Flash skills a plus but not required. Multi-Lingual
is bonus.
Please
email resume and cover letter, indicating job code to
jobs@childhooddiseases.org
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