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[新项目] [BOINC] [生命科学类] Center For Structural Biology

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发表于 2008-7-16 10:17:02 | 显示全部楼层 |阅读模式
项目全名是:Drug Discovery through Computational Structural Biology and Chemistry,大概算是最长的项目名了吧。。。

http://boinc.vanderbilt.edu/CSB/

Research in our laboratory seeks to fuse computational and experimental efforts to investigate proteins, the fundamental molecules of biology, and their interactions with small molecule substrates, therapeutics, or probes. We develop computational methods with three major ambitions in mind: 1) to enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses; 2) design proteins with novel structure and/or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways, and 3) understand the relation between chemical structure and biological activity quantitatively in order to design more efficient and more specific drugs. Crucial for our success is the experimental validation of our computational approaches which we pursue in our laboratory or in collaboration with other scientists.

Current research focuses on entirely new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson’s, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.

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参与人数 1基本分 +30 维基拼图 +1 收起 理由
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 楼主| 发表于 2008-7-16 10:17:22 | 显示全部楼层
目前的BOINC BCL Fold Protein程序只在linux平台有,多之前BOINC BCL Test来看,应该比较快就会有windows平台的版本。
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 楼主| 发表于 2008-7-17 09:46:07 | 显示全部楼层
June 5, 2008
The server is up and running thanks to help from ITS, especially Troy Osborn. No applications are ready yet, but stay tuned.

服务器已经正式运行,虽然计算程序还没准备好。

June 5, 2008
The Computational Structural Biology project begins.

CSB项目开始。

June 17, 2008
A test application to incorporate the BCL (a C++ BioChemistry Library) and BOINC environments has been implemented and tested on Linux and Windows architectures.

测试程序。

July 3, 2008
The CSB project is approaching production stage. Thanks to all that have signed up (and encountered errors). I hope you will stay to participate once the project is up and running full time.

CSB项目的开发快要完成了。

July 16, 2008
A protein folding application is being developed and tested. Be prepared for errors and other nasties while this is going on.

正在开发一个蛋白质折叠的计算程序。

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参与人数 1基本分 +15 维基拼图 +7 收起 理由
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 楼主| 发表于 2008-8-1 22:35:47 | 显示全部楼层
已经改名叫 BCL@Home 了。。。

Drug Discovery through Computational Structural Biology and Chemistry using the BioChemistry Library (BCL)

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参与人数 1基本分 +10 维基拼图 +2 收起 理由
霊烏路 空 + 10 + 2

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