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[已完成翻译] [FAAH]刚发现的两个化合物铺平了生产抗艾新药物的道路

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发表于 2010-3-30 08:59:11 | 显示全部楼层 |阅读模式
来源:http://www.distributedcomputing.info/news.html
原载:PR Newswire - http://www.prnewswire.com/news-releases/two-compounds-discovered-that-pave-the-way-for-new-class-of-aids-drug-85830882.html
标题:Two Compounds Discovered That Pave the Way for New Class of AIDS Drug - 刚发现的两个化合物铺平了生产抗艾新药物的道路
作者:
日期:2010年3月2日
概要:介绍了两个对抗艾滋病的化合物发现的过程,以及 IBM 主持的 WCG 项目的概况。

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发表于 2010-3-31 10:39:18 | 显示全部楼层
本帖最后由 hawkwolf 于 2010-3-31 10:41 编辑

IBM World Community Grid's computing strength powers breakthrough research that will guide their development

IBM全球社区网格(WCG)的强大计算力推动其指导的项目取得了突破性进展

摘自:LA JOLLA, Calif., March 2 /PRNewswire-FirstCall/ --
视频:http://origin-qps.OnstreamMedia. ... 2589-20100302-1.flv

A team of researchers at the renowned Scripps Research Institute has discovered two new compounds that prove the existence of new binding sites on HIV protease.  Associate Professor C. David Stout, senior author of the study, explained "These results open the door to a whole new approach to drug design against HIV protease," which is an enzyme used by HIV to create new, infectious viral particles.  

一个在Scripps研究所的研发小组,已经在被确定的两个HIV蛋白酶的新结合位点上发现了两种新化合物。主持这项研究的副教授 C. David Stout 解释说:“这些结果为设计全新的抗艾滋病蛋白酶药物上,开辟了一个新局面,”这种酶是HIV病毒用于复制、产生新病毒的一种感染性颗粒。

According to the World Health Organization, about 33 million people currently live with HIV infections.  Several drugs used to treat AIDS inhibit this HIV protease target, but drug-resistant mutants that impede the effectiveness of these drugs keep appearing and getting worse.  

根据世界卫生组织(WHO)统计,现今约有3千3百万人被HIV感染,许多用于治疗艾滋病的药物的机理是抑制这类HIV蛋白酶的作用,但病毒在抗药性上的突变,制约了这些药物的效果,而且病毒不断出现新突变,状况变得越来越糟糕。

Two members of the FightAIDS@Home team, Research Associate Alex L. Perryman, Ph.D., and Professor Arthur J. Olson, were part of this innovative research and are now working to extend it.  This experimental breakthrough will serve as the basis for new drug development to combat the increasing number of drug-resistant HIV strains and to improve the potency of current drug therapies.   The results form the groundwork for a new class of more powerful treatments to fight HIV/AIDS. The findings appear as the March cover story in the journal Chemical Biology and Drug Design.

To view video news release, visit: http://www.youtube.com/watch?v=G5iCBsUsDSQ

两位FightAIDS@Home团队的成员,研究助理 Alex L. Perryman 博士 和 教授 J. Olson,这项革新技术的参与者,正在努力扩展这项研究。 这项试验上的突破将有助于研发抗击不断增长的耐药性HIV变种的新药物,并能改善现有药物的治疗效果。这些结果形成了新式的、更强大的治疗HIV/AIDS依据,这个发现已经上了化学生物学与药物设计杂志3月份刊的封面文章。
点击这里观看新发布的视频: http://www.youtube.com/watch?v=G5iCBsUsDSQ


Utilizing computing power from 1.5 million devices networked through IBM's ( IBM) World Community Grid, the new sites on the HIV protease are being used as docking targets for virtual screening experiments, in order to guide the development of these chemical compounds into a new class of potent HIV inhibitors.  Using the massive computational resources of the World Community Grid, the FightAIDS@Home team has already docked over 500,000 compounds against these newly characterized binding sites.

利用WCG上联网的一百五十万台电脑形成的巨大计算能力,新的HIV蛋白酶结合点正作为结合靶用于虚拟筛选试验中,这将指导新一级的HIV化合物抑制剂的开发。通过利用WCG的巨大计算资源,FightAIDS@Home小组已经在这些新特征结合位点上结合了超过50万种化合物。

By aggregating the unused cycle time of 1.5 million personal computers donated by volunteers in over 80 countries, World Community Grid is now the world's largest public humanitarian grid, equivalent in power to a Top 15 supercomputer, and crunched more than 107,000 years of computational time in just 5 years for the Scripps Research Institute project, providing more than 104 million calculations.

"IBM's World Community Grid and its volunteers help us run millions of computations to evaluate the potential interactions between compounds and mutant viral proteins," said Dr. Arthur J. Olson, Anderson Research Chair Professor, Department of Molecular Biology at The Scripps Research Institute.  "Through this effort we were able to significantly speed up our investigation.  Without the computational power of World Community Grid, it would have taken us many more years to get to this important step in our research."

Once the HIV virus enters a human cell, it uses a small set of proteins called enzymes to force the cell to produce many new copies of itself, which then go on to infect other cells.  Most HIV drugs work by blocking the operation of one or more of these enzymes.  In the current work, the Scripps researchers are looking for new compounds that will stabilize the inhibited conformation, or shape, of the HIV protease enzyme, and thus help stop the virus from replicating.  Because HIV mutates so frequently, some drugs that inhibit the enzyme from replicating are no longer working, or are not working as effectively.  By running calculations on the World Community Grid FightAIDS@Home project, the team at Scripps is trying to develop new drugs that bind to more parts of the mutant enzyme, thereby shutting it down more effectively.  

超过80个国家的志愿者们,贡献了一百五十万台个人电脑的闲置计算时间,现在的WCG成为了全球最大的公共人道主义网格,其计算能力相当于一台位列全球15强的超级计算机, 仅在5年的时间里,就为Scripps研究所提供了相当于其现有计算能力要运行10万7千年的运算时间, 完成了超过1.04亿次计算。

“IBM的WCG和它的志愿者们,帮助我们运行了数百万次计算,以评估化合物和变异病毒蛋白质之间潜在的交互作用。通过这种尝试,我们已能够极大地加快试验进度。如果没有WCG的巨大计算力,我们的研究步伐会被推后很多年。”,Dr. Arthur J. Olson,这位来自Scripps研究所分子生物学部的安德森研究首席教授是这么评价的。

当HIV病毒进入人的细胞,它用一系列被称为酶的小蛋白质来迫使细胞来生产众多它自己的复制品,然后它们再去感染其他细胞.  绝大多数HIV药物的功效是阻止这些酶的一个或多个功能. Scripps的研发人员,当前的工作是在寻找新的化合物来稳定HIV蛋白酶在被抑制状态的构造或形状,这有助于中断病毒的自我复制.由于HIV病毒突变太频繁,一些药物在病毒复制过程中抑制酶的效果并不长久,或根本没有了效果. 通过运行在 World Community Grid平台上的FightAIDS@Home项目, Scripps开发团队正在努力开发新药物以能在这种突变的酶上结合更多的部分,从而更加有效地关闭它的功能.


World Community Grid speeds up humanitarian research by providing scientists with millions of dollars of supercomputer power, for free, that would otherwise not be available to them.

WCG通过给科学家们提供价值数百万元的超级计算机才有的计算能力,推动了人道主义研究的进程,当然,这个计算力是免费的,要不这些科学家们也不会采用它。

In a second paper recently published in the Journal of Molecular Biology, the Scripps team has used computational modeling to improve understanding of another HIV enzyme and key drug target - integrase.  Integrase, along with protease and a third enzyme, reverse-transcriptase, is one of three key proteins that allow the HIV virus to take over the cellular machinery of the host cell and replicate itself.  By producing a more accurate model of integrase, the research allows further searches for new drug molecules that will inhibit the mutant drug resistant forms of this enzyme, as well. The Scripps team was recently awarded government stimulus funding as part of the American Recovery and Reinvestment Act to advance their new project against HIV integrase.

在已发行的化学生物学与药物设计杂志的第二页上,Scripps团队已经使用计算机建模来增进对整合酶、另一种HIV蛋白酶与靶向药物的研究。整合酶、蛋白质上的一个第三方蛋白酶,是三个关键性蛋白质之一,它使HIV病毒能接管宿主细胞的细胞机构来自我复制。通过构建更精确的整合酶模型,这技术使未来未来搜寻新的药物分子成为可能,这些新药物分子将能通过稳定病毒蛋白酶的结构来抑制突变病毒的抗药性。Scrrips团队近期已获得按照美国恢复和再投资法案规定的政府促进基金,来促进他们在HIV整合酶方面的新研究。

"The volunteers around the world who donate their computer time have helped usher in a potentially new class of drugs that may save lives and increase the quality of life for people living with HIV," said Dr. Joseph Jasinski, Distinguished Engineer and Program Director of IBM's Healthcare and Lifesciences Institute.  "World Community Grid enables a smarter way to conduct promising research by providing unprecedented computing power to projects that might not be positioned to make a difference in the world without access to a free supercomputer."

“世界各地的志愿者们,贡献了他们电脑的计算时间,已经在帮助研究人员开发潜在的新药物,这些药物将能拯救无数生命,并能提高艾滋病感染者的生存质量。WCG为有前景的研究开拓了一条更明智的道路,通过给这些研究提供了史无前例的巨大计算力,这些项目如果没有这个免费的超级计算机恐怕就无法致力于改进我们的世界。”IBM的医疗保健和生命科学研究所的杰出工程师和计划负责人,Dr. Joseph Jasinski 说的 有些道理。

The FightAIDS@home project will continue to run calculations to further this research against drug-resistant mutant "superbugs" of HIV.

"In the fight against HIV/AIDS it is important to remind people that HIV has not gone away, and that there are many things still to be done," said Joe Solmonese, President of the Human Rights Campaign.  "World Community Grid is one way to get involved and makes it easy to contribute to this important research in a meaningful and effective way."

To donate your computer cycle time to humanitarian research covering areas from cancer to more nutritious rice to more efficient energy sources, please visit: www.worldcommunitygrid.org.  From this site you can install a small, safe, and secure program that will connect you to the grid.  When your computer is idle, data is requested from World Community Grid's server to perform a computation.  Once finished, the result is sent back to the server, prompting it for a new piece of work.  It is not necessary to leave a computer on more than usual and we encourage members to continue their normal routines.  We can harvest substantial computational power during a normal work day just by taking advantage of the time when someone is on the phone, talking with colleagues, taking a coffee break or doing simple tasks that don't require the full power of the computer.

FightAIDS@home将持续计算下去,以促进在抗击有耐药性的、突变的HIV“超级病毒”方面的研究。
“在抗击HIV/AIDS的斗争中,最重要的是要提醒人们,HIV病毒不会自己消亡,还有很多工作等着我们去完成。 给重要的研究提供有意义而有效的贡献,加入WCG是一个简单的参与方式”,人权运动主席,Joe Solmonese是这么认为的。

把您的闲置运行时间贡献给人道主义研究,这些研究覆盖了从癌症到使稻米更具营养,甚至是高效的能源, 请访问:www.worldcommunitygrid.org。 您可以从这个网站上安装一个小的、安全的、并可靠的程序,这个程序会让你连接这计算网格。 当您的电脑空闲时,这程序会从WCG服务器取得数据并开始运算。一旦计算完成,结果会被发送回服务器,程序并要求新的数据用于计算。您不必为了计算而让电脑闲置,和平常一样使用电脑为好,我们鼓励志愿者们按照自己正常日程使用电脑。 我们可以在您正常工作状态下就可以收集到巨大的计算力,利用的是时间优势,例如:您打电话的时候、和同事聊天的时候、喝杯咖啡休息一下的时候,或者在只运行简单的工作程序、而用不上电脑的全部计算力的时候。



Other projects running on World Community Grid have produced results including:

The Help Defeat Cancer project proved their more accurate technique for identifying cancer and received a $2.5 million grant from NIH to further deploy its system.
Discovering Dengue Drugs Together project has identified potential antiviral compounds and is continuing with laboratory work on those.
Nutritious Rice for the World project has already returned 12 million transactions and 11,000 years of compute time.

运行在WCG平台上,已取得成果的其他项目如下:

Help Defeat Cancer project,对抗癌症项目。此项目证实了他们的技术在诊断癌症方面更精确,并且获得了美国国立卫生研究院(NIH)$ 250万的拨款以进一步部署它的系统。

Discovering Dengue Drugs Together project,一起探索登革热药物项目。 此项目已经证实了不少潜在的抗病毒化合物,现在正在进行药物试验。

Nutritious Rice for the World project,世界营养水稻项目。此项目现已回收了1200万条结果,折合成计算时间大约是一万一千年。

评分

参与人数 2基本分 +100 维基拼图 +90 收起 理由
BiscuiT + 100 + 60
霊烏路 空 + 30

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发表于 2013-5-5 17:17:36 | 显示全部楼层
本帖最后由 arthur200000 于 2013-5-6 18:14 编辑

老坑。。。。
世界各地的志愿者们,贡献了他们电脑的计算时间

貌似逗号多余了(我在刷分数我会乱说)
has discovered two new compounds that prove the existence of new binding sites on HIV protease
已经在被确定的两个HIV蛋白酶的新结合位点上发现了两种新化合物

哪里是被动语态?
变成已经确定,的也多余了。
in order to guide the development of these chemical compounds into a new class of potent HIV inhibitors.
将指导新一级的HIV化合物抑制剂的开发

用于指导新一层次~~化学抑制剂~~~
To donate your computer cycle time to humanitarian research covering areas from cancer to more nutritious rice to more efficient energy sources,
把您的闲置运行时间贡献给人道主义研究,这些研究覆盖了从癌症到使稻米更具营养,甚至是高效的能源

为了把你的⋯⋯覆盖了⋯⋯等方面
没有可以刷分数的了。。。
写完整的话就是为了把您的闲置运行时间贡献给人道主义研究,这些研究覆盖了从癌症到使稻米更具营,甚至是高效的能源等方面
@昂宿星团人  

点评

欢迎继续这样找茬喵~话说最后一句什么意思?  发表于 2013-5-5 23:23

评分

参与人数 1维基拼图 +12 收起 理由
昂宿星团人 + 12 就是这种小错误的存在才需要校对这一步骤,.

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