Mission
The mission of the GO Fight Against Malaria project is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of malaria. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested and further developed into possible treatments for the disease.
Significance
Malaria is one of the three deadliest infectious diseases on earth and is caused by parasites that infect both humans and animals. Female mosquitoes spread the disease by biting infected hosts and passing the parasites to other hosts that they bite later. When these parasites replicate themselves in red blood cells (which the parasites use for food), the symptoms of malaria appear. Malaria initially causes fevers and headaches, and in severe cases it leads to comas or death. Plasmodium falciparum, the parasite that causes the deadliest form of malaria, kills more people than any other parasite on the planet. Over 3 billion people are at risk of being infected with malaria.
Although there are many approved drugs that are able to cure malarial infections, multi-drug-resistant mutant "superbugs" exist that are not eliminated by the current drugs. Because new mutant superbugs keep evolving and spreading throughout the world, discovering and developing new types of drugs that can cure infections by these multi-drug-resistant mutant strains of malaria is a significant global health priority.
Approach
Scientists at The Scripps Research Institute of La Jolla, California, U.S.A., will use IBM's World Community Grid to computationally evaluate millions of candidate compounds against different molecular drug targets from the malaria parasite. If these target molecules can be disabled, then patients infected with malaria can potentially be cured. The computations will estimate the ability of the candidate compounds to disable the particular target molecules needed by the malaria parasite to survive and multiply. Particular priority will be given to targets and candidate compounds which could attack the multi-drug-resistant mutant "superbug" strains of the malaria parasite. The power of World Community Grid can reduce to one (1) year what would take at least one hundred (100) years to complete using the resources normally available to the researchers at The Scripps Research Institute. The results computed on World Community Grid will be available in the public domain for all scientists to use and build upon in their research to develop drugs to fight malaria.
Go Fignt Against Malaria项目的目的在于寻找可能能够改善疟疾抗药性的潜在药物。World Community Grid的计算能力将被用来模拟成千上万化学组分以及特定的目标蛋白质之间的相互作用，并以此来推测其消除疟疾的能力。最佳的组分将被测试，并可能用于日后的治疗中。
疟疾是世界三大致命传染病之一。它是由能够传染人和动物的寄生虫引起的。母蚊子通过叮咬感染者并叮咬其他未感染者的方式将该疾病传播。当寄生虫以红细胞为食并在血液里繁殖时，疟疾的症状便显现出来。疟疾最初引起头痛与发热，严重时会引发昏迷甚至死亡。恶性疟原虫是造成最多死亡的疟原虫种类。超过30亿人面临着感染疟疾的危险。
尽管目前有很多药物能够治疗疟疾，但是对于那些对多种药物均产生抗药性的”超级疟原虫“来说目前的药物无法奏效。因为这些超级疟原虫正在不断的繁殖并传播，研发能够消灭这些疟原虫的新型药物的开发工作是一项重要的全球健康优先考虑问题。
美国加尼佛尼亚州拉霍亚境内的斯克里普斯研究机构的工作人员将利用IBM的World Community Grid来对成千上万种化学组分进行与来自疟疾寄生虫的药物分子的对抗模拟。如果这些目标药物分子能够被失活，那么那么疟疾患者将有被医治的可能性。模拟主要检测化学组分使那些能够让寄生虫存活并繁殖所必须的分子失活的能力。那些能够攻击”超级疟原虫“种类的候选组分将被优先（研究）。World Community Grid能够将研究机构使用至少一百年才能完成的任务缩短至一年完成。其结果将向公众开放并被科学家用于开发对抗疟疾的新型药物中。
第四段：加州一般应该是写成加利福尼亚的，吧。。
la jolla →亚荷拉
computationally evaluate millions of candidate compounds against different molecular drug targets from the malaria parasite. →通过计算的方式评估针对于疟原虫体内不同分子药物靶点的上百万种化学组分
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