FightMalaria@Home
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FightMalaria@Home | |
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FightMalaria@Home logo | |
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| 优化程序 | |
| 计算特点 | CPU密集： |
| 官方网址 | [ FightMalaria@Home] |
| [[Image:Rss_icon.png|]] | [ 通过 RSS 获取项目新闻] |
Crowd-sourcing antimalarial drug discovery Goal: To discover novel targets for antimalarial drugs. Context: Malaria kills a child every 45 seconds. The disease is most prevalent in poorer countries, where it infects 216 million people and kills 650,000 each year, mostly African children under 5 years old [WHO]. And Plasmodium falciparum continues to evolve resistance to available medication. We therefore urgently need to discover new drugs to replace existing drugs. Importantly, these new drugs need to target NEW proteins in the parasite. The FightMalaria@Home project is aimed at finding these new targets. Resources: The Plasmodium falciparum genome has been sequenced, the proteome has been mapped, and protein expression has been confirmed at various stages in this apicoplexan's life cycle. Numerous crystal structures of target proteins are also available, and the remainder have been modelled using available structural templates. Excitingly, large research organisations (GSK, Novartis) have already tested millions of compounds and found nearly 19,000 hits that show promising activity against Plasmodium falciparum [MMV]. But they don't know which target protein is inhibited by these compounds. Drug discovery and development will be significantly enhanced by knowing the target protein for each of these hits. Problem: We plan to dock each of the 18,924 hits into structures of each of the 5,363 proteins in the malaria parasite. The computational power needed is enormous. Solution: We aim to harness the donated computational power of the world's personal computers. Most computers only use a fraction of their available CPU power for day-to-day computation. We have built a BOINC server that distributes the docking jobs to donated 'client' computers, which then do the work in the background. By connecting 1000s of computers this way, we'll be able harness the equivalent power of large supercomputers. If you would like to get involved, please follow the very quick installation instructions here
如何加入项目
该项目基于 BOINC 平台，简要的加入步骤如下（已完成的步骤可直接跳过）：
- 下载并安装 BOINC 的客户端软件（官方下载页面或程序下载）
- 点击客户端简易视图下的“Add Project”按钮，或高级视图下菜单中的“工具->加入项目”，将显示向导对话框
- 点击下一步后在项目列表中找到并单击选中 [[]] 项目（如未显示该项目，则在编辑框中输入项目网址： ），然后点击下一步
- 输入您可用的电子邮件地址，并设置您在该项目的登录密码（并非您的电子邮件密码）
- 再次点击下一步，如[server_status.php 项目服务器]工作正常（并且有适合自身操作系统的[apps.php 计算程序]），即已成功加入项目
更详细的加入方法说明，请访问 BOINC 新手指南 或 BOINC 使用教程。
本站推荐您加入 Team China 团队，请访问项目官方网站的 [team.php 团队检索页面]，搜索（Search）并进入 Team China 的团队页面，点击页面中的 Join 并输入用户登录信息即可加入！
