开始翻译 WCG 官方网站，research 部分

碧城仙

开始翻译 WCG 官方网站，research 部分

有待翻译的页面列表如下：

1、 http://www.equn.com/wcg/research/index.htm

2、 http://www.equn.com/wcg/research/submitaproposal.htm

3、 http://www.equn.com/wcg/research/faahresearch.htm

4、 http://www.equn.com/wcg/research/faahabout.htm

5、 http://www.equn.com/wcg/research/faahpart.htm

6、 http://www.equn.com/wcg/research/hpfresearch.htm

7、 http://www.equn.com/wcg/research/hpfabout.htm

8、 http://www.equn.com/wcg/research/hpfpart.htm

9、 http://www.equn.com/wcg/research/projectarchives.htm

Musi_Zhang

fanyi wanle zenme shangbao

Youth

直接贴在帖子里就好了：）

碧城仙

这个帖子是一年多前发的，那几个待翻译的页面对应的官方网站内容早已更新了许多，如果您有兴趣，可以翻译 http://www.worldcommunitygrid.or ... ase/viewResearch.do 里面的主要内容。

Musi_Zhang

这个贴？~~

碧城仙

这个帖发了一年零两个月了，一直没人搭理。而且 WCG 的翻译也长久没人关心了。

慢舟

我试一下吧。

慢舟

Help Cure Muscular Dystrophy (Launched December 19, 2006)
World Community Grid and researchers supported by Decrypthon, a partnership between AFM (French Muscular Dystrophy Association), CNRS (French National Center for Scientific Research) and IBM are investigating protein-protein interactions for 40,000 proteins whose structures are known, with particular focus on those proteins that play a role in neuromuscular diseases. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular macromolecules, hopefully leading to better treatments for muscular dystrophy and other neuromuscular diseases. more

For specific questions about the Help Defeat Muscular Dystrophy Project, please go to the Help Cure Muscular Dystrophy Project FAQs.

帮助治愈进行性肌萎缩症(始于2006年12月19日)
由Decrypthon计划资助的研究者与World Community Grid开始一项研究四万种已知结构蛋白质间相互作用的项目，特别针对与神经肌肉疾病有关的蛋白质。Decrypthon计划是由AFM (法国抗进行性肌萎缩症协会，French Muscular Dystrophy Association), CNRS (法国国家科学研究中心，French National Center for Scientific Research)和IBM公司共同发起的。项目生成的信息数据库有助于帮助研究者设计出所需要的分子，这种分子能够增强或者抑制特定大分子间的结合，希望能够改善进行性肌萎缩症或其它神经肌肉疾病患者的处境。>>更多内容
更多有关“帮助战胜进行性肌萎缩症”（the Help Defeat Muscular Dystrophy Project）项目的问题，请访问Help Cure Muscular Dystrophy Project FAQs(英文)

[ 本帖最后由 慢舟 于 2007-3-3 13:47 编辑 ]

zglloo

翻译能力有限  尝试下
Smallpox Research Grid Project  

Accelerating the Discovery of a Smallpox Cure
The United Devices Smallpox Research Grid Project, sponsored by IBM in conjunction with several other Research Participants, employed computational chemistry on a massive distributed computing grid to analyze candidates for a medical therapy to fight the smallpox virus.


United Devices (external site)
Grid.org Research Participants (external site)

Combining computer-based screening with grid technology, the project allowed scientists to screen 35 million potential drug molecules against several smallpox proteins to identify good candidates for developing into smallpox treatments.

  
Drug Discovery Timeline Reduced from Years to Weeks
One of the largest computational projects ever undertaken, the Smallpox Research Grid Project shaved years off the time required to perform screening of this scale.

In the first 72 hours, 100,000 results were returned. Overall, the project identified 44 strong treatment candidates.

Based on the success of the Smallpox study, World Community Grid was created with the goal of creating a technical environment where other humanitarian research could be processed.

天花研究网格项目
加快UD发现一种治疗天花和天花器件研究网工程 由IBM公司与其他几个研究参与者 受聘于大规模分布式计算化学分析网格计算医学疗法来医治天花 病毒.

United Devices (外部网站)
Grid.org Research Participants (外部网站)
结合计算机与网格技术筛选，该项目允许科学家进行筛选35亿种，类潜在药物分子对蛋白质天花 并找出好几个候选人发展成治疗天花.  

药物研究从曾今一年缩短到周期
其中此项目是有史以来大规模运算的天花网格项目来进行筛选.          -(感觉拿不准确)

基于成功的天花研究 World Community Grid 的目标是创造一个技术环境下创造科研可以处理其他人道主义 。

[ 本帖最后由 zglloo 于 2007-3-6 18:05 编辑 ]

慢舟

Fiocruz Genome Comparison (Launched November 21, 2006)
World Community Grid and the Oswaldo Cruz Institute, Fiocruz, will be comparing genomic information to improve the quality and interpretation of biological data and our understanding of biological systems, host-pathogen and environmental interactions. This information can play a critical role in the development of better drugs and vaccines, and improved diagnostic procedures. more

For specific questions about the Genome Comparison Project, please go to the Fiocruz Genome Comparison FAQs.
Fiocruz 基因比较(始于2006年11月21日)


>>更多内容
更多有关“”（the Genome Comparison Project）项目的问题，请访问the Fiocruz Genome Comparison FAQs.(英文)

最近事儿多，有空再弄。

airwolfliu

http://www.worldcommunitygrid.or ... cmd/viewHcmdMain.do

Help Cure Muscular Dystrophy
    World Community Grid and researchers supported by Decrypthon, a partnership between AFM (French Muscular Dystrophy Association), CNRS (French National Center for Scientific Research) and IBM are investigating protein-protein interactions for 40,000 proteins whose structures are known, with particular focus on those proteins that play a role in neuromuscular diseases. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular macromolecules, hopefully leading to better treatments for muscular dystrophy and other neuromuscular diseases.

帮助治疗肌肉萎缩症
世界公共网格计算平台和一个与 AFM(法国肌肉萎缩症协会)、CNRS(法国国家科学研究中心)以及IBM合作的机构Decrypthon支持的研究员共同研究40，000个已知结构的蛋白质的相互作用，特别关注那些在神经肌肉疾病中扮演重要角色的蛋白质上。已建立的信息数据库将帮助研究人员设计出可抑制或可加强约束力的特殊的巨大分子，这样对治疗肌肉萎缩症和其它神经肌肉的疾病就更有希望了。

What is neuromuscular disease and muscular dystrophy?
Neuromuscular disease is a generic term for a group of disorders (more than 200 in all) that impair muscle functioning either directly through muscle pathology (muscular dystrophy) or indirectly through nerve pathology. Most of them are rare (affecting less than one person in 2,000), have a genetic origin (80%) and affect both children and adults. These chronic diseases lead to a decrease in muscle strength, causing serious disabilities in motor functions (moving, breathing etc.). Disease expression is variable; some disorders are progressive, while others remain stable for several years, and the same disease can cause different symptoms from one person to the next.
Despite advances in therapeutic techniques, there is currently no curative treatment available for persons affected by neuromuscular diseases.

什么是神经肌肉疾病和肌肉萎缩症？
神经肌肉疾病是表示一系列神经紊乱状态的专业术语（总共超过200种状态）。这种疾病或是直接通过肌肉（肌肉萎缩症）或是间接地通过神经来削弱肌肉的功能。大多数的这类疾病是罕见的（影响范围约每2000人中不到一人）。这类疾病通常是由遗传引起的（遗传占80%）并且对儿童和成年人都有影响。这些慢性疾病会导致肌力的衰减，造成严重的运动能力丧失（例如移动，呼吸等）。该疾病有多种表现形式，一些会发展导致病变，而其它的在数年内都会保持稳定。相同的疾病对不同的人会产生不同的症状。
不论医疗技术如何先进，当前还没有什么药物能有效的治疗那些受神经肌肉疾病侵袭的人们。

airwolfliu

http://www.worldcommunitygrid.or ... cmd/viewHcmdPart.do

Research Participants
The Molecular Docking Project, led by Dr. Alessandra Carbone from the "Pierre et Marie Curie" University in Paris, is associated with specialized teams implicated in grid computing (Jean-Marie Chesnaux from CNRS: French National Center for Scientific Research), molecular modeling (Richard Lavery from CNRS), and genetic analysis of myopathies (Pascale Guicheney from INSERM, French Public Health Research Institute).

Computational biology: Dr. Alessandra Carbone team, Analytical Genomics, Analytical Genomics, INSERM Laboratory U511, Faculty of Medicine, "Pierre et Marie Curie" University, Paris.

Grid computing: Jean-Marie Chesneaux team , Informatic Laboratory of Paris 6 (LIP6), CNRS Laboratory UMR 7606, "Pierre et Marie Curie" University, Paris.

Myopathies: Pascale Guicheney team, INSERM Laboratory U582, Myology Institut, "Pitié-Salpetrière" Hospital, Paris.

Molecular modelling: Richard Lavery team, Laboratory of theoretical biochemistry, CNRS Laboratory UPR9080, "Institut de Biologie Physico-Chimique", Paris.

参与研究者
抑制剂项目由巴黎皮埃尔玛丽居里大学的Alessandra Carbone博士领导，包括联合了网格计算中的许多专业团队（Jean-Marie Chesnaux来自CNRS：法国国家科学研究中心），分子造摸（Richard Lavery来自CNRS），以及肌病遗传分析（Pascale Guicheney来自INSERM，法国公共卫生研究所）。
生物学计算：Alessandra Carbone博士小组，基因分析，INSERM U511实验室，巴黎皮埃尔玛丽居里大学医学系。
网格计算：Jean-Marie Chesneaux小组，巴黎信息科学实验室（LIP6），CNRS实验室UMR7606，巴黎皮埃尔玛丽居里大学。
肌病：Pascale Guicheney小组，INSERM实验室U582，肌肉学协会（Myology Institut），巴黎Pitié-Salpetrière医院。
分子造摸：Richard Lavery小组，生化理论实验室，CNRS实验室UPR9080，巴黎生物医学研究所（Institut de Biologie Physico-Chimique）。

红色的可能不准确，请校对

airwolfliu

http://www.worldcommunitygrid.or ... md/viewHcmdAbout.do

About the Project
From genes to pathogenesis
In 1986, the first gene – the dystrophin gene – implicated in Duchenne dystrophy, the most common form of muscular dystrophy, was identified. Since that time, thanks to the power of genetic analysis, more than 200 genes that cause neuromuscular disease are now known. However, the function and the interactions of the corresponding proteins, which are encoded by these genes, are still generally unknown. While enhancing our knowledge, the number of genes identified has also revealed the overall complexity of the pathogenesis of these diseases.
All cells of an organism contain the same genetic information in the form of DNA, which makes up the genome. The expression of genes (more than 20,000 have been identified in humans) contained in the genome leads to the production of proteins (more than 45,000 have been described, with each gene coding for 1.6 proteins on average), which ensure the functioning of cells, with specificities depending on the organs, such as muscles. Some of these proteins are enzymes; some are signaling molecules; others are receptors that bind to other molecules named ligands with high affinity and specificity (like the functioning of a key and a lock); and others are structural proteins. The conformation of the protein in space (3D-structure) determines their interactions and its function.
The functioning of muscles depends on numerous proteins. These proteins are localized and act at different levels of the muscle cell itself, the cell body, or the motor nerve axon – which excites the muscle, or at the junction between the nerve and the muscle.
Most neuromuscular diseases are due to genetic modifications (mutations in certain genes leading to mutations in the corresponding protein) that lead to non-functional or partly-functional proteins or even no protein at all. The neuromuscular disease will be different according to the protein and the site of the protein affected by the mutation.
In order for researchers to understand how neuromuscular diseases prevent proteins from performing their necessary functions to maintain muscle and nerve health, a better and more detailed understanding of function and interactions of proteins involved in the pathogenesis of each muscular dystrophy is required.
Knowing the function and interactions of proteins is also critical for helping researchers to design therapeutic strategies. Without this vital knowledge, scientists will not be able to develop innovative therapies that will lead to treatments for the vast majority of neuromuscular diseases.

关于此项目
从基因到发病机理
在1986年，第一个基因——营养不良基因——用于鉴定包括杜兴肌营养不良症和大多数普通的肌肉萎缩症。从那时起，感谢遗传分析的力量，现在超过200种导致神经肌肉疾病的基因被识别。可是，对有相应功能和交互作用的蛋白质进行编码的基因却仍为被识别。当我们的知识面扩展到能被识别大多数基因的时候，还是不能了解这些疾病发病机理的全部。
生物体内包含的所有细胞的基因组都是由同一种遗传信息以DNA的形式所构成的。表达基因（超过20，000种人类表达基因已被识别）包含构成蛋白质的基因组（有超过45，000中已被定义，平均每个基因编码1.6个蛋白质），其作用是依靠器官的特异性来确保细胞的机能，诸如肌肉。其中一些蛋白质是酶，一些是信号分子，另外一些是与被称为有高亲和力和特异性的分子结合的受体（就像钥匙和锁的机能）；还有一些是结构蛋白质。蛋白质的空间构造（三维构造）决定他们的相互作用和功能。
肌肉的机能取决于众多的蛋白质。这些蛋白质被存贮或使用在不同级别的肌肉细胞本身，细胞体，或者是运动神经轴突——可刺激肌肉，或者是在神经和肌肉的结合处。
大多数神经肌肉疾病都是由于遗传修饰（某个基因的变化会导致相应的蛋白质产生转变）导致产生无机能或只有部分机能的蛋白质，以至根本没有蛋白质产生。神经肌肉疾病将依照不同的蛋白质和受转变影响的蛋白质位置而定。
为了使研究者能了解神经肌肉疾病是怎样阻止蛋白质进行它们必要的功能，为肌肉和神经健康提供营养。更好更详细的了解关于每一种肌肉萎缩症的发病机理中蛋白质的功能和交互作用是必要的。
鉴定已知的蛋白质的功能和作用将帮助研究人员设计出治疗方案。没有这些重要的知识，科学家将不可能为绝大多数神经肌肉疾病患者改善他们的治疗。





后半部分还在翻译中...

第三类接触

wcg我来包办。
现已翻译——
http://www.worldcommunitygrid.org/index.jsp
http://www.worldcommunitygrid.org/about_us/viewOurPartners.do
http://www.worldcommunitygrid.org/about_us/viewAdvisoryBoard.do
http://www.worldcommunitygrid.or ... ewNewsletterMain.do
http://www.worldcommunitygrid.org/about_us/viewBecomePartner.do
http://www.worldcommunitygrid.or ... wSubmitAProposal.do
http://www.worldcommunitygrid.org/viewTellAFriend.do
http://www.worldcommunitygrid.or ... dComputingBasics.do
http://www.worldcommunitygrid.org/about_us/viewAboutUs.do

http://www.worldcommunitygrid.or ... ase/viewResearch.do
http://www.worldcommunitygrid.or ... cmd/viewHcmdMain.do
http://www.worldcommunitygrid.or ... md/viewHcmdAbout.do
http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdPart.do
http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdFaq.do?shortName=hcmd
http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdAgentFaq.do

http://www.worldcommunitygrid.org/projects_showcase/fgc/viewFgcMain.do
http://www.worldcommunitygrid.org/projects_showcase/fgc/viewFgcAbout.do


全归我了~

[ 本帖最后由 第三类接触 于 2007-4-15 00:06 编辑 ]

airwolfliu

我靠~~这还有抢生意的啊